Novel VKORC1 Mutations Associated with Warfarin Sensitivity
نویسندگان
چکیده
منابع مشابه
Polymorphisms of VKORC1 and CYP2C9 are associated with warfarin sensitivity in Chinese population
OBJECTIVE Warfarin is a commonly prescribed anticoagulant for prevention of thromboembolic events. Wide inter-individual dose variation, narrow therapeutic range and risk of serious bleeding result in difficulties in achieving the therapeutic effect. The present study was designed to clarify the real biological significance of the polymorphisms of VKORC1 and cytochrome P450 2C9 (CYP2C9) in warf...
متن کاملA novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.
Warfarin, a commonly prescribed anticoagulant, exhibited large inter-individual and inter-ethnic differences in the dose required for its anticoagulation effect. Asian populations, including Chinese, require a much lower maintenance dose than Caucasians, for which the mechanisms still remain unknown. We determined DNA sequence variants in CYP2C9 and VKORC1 in 16 Chinese patients having warfarin...
متن کاملNovel regulatory variant detected on the VKORC1 haplotype that is associated with warfarin dose.
AIM Warfarin dose requirement is associated with VKORC1 rs9923231, and we studied whether it is a functional variant. MATERIALS & METHODS We selected variants in linkage disequilibrium with rs9923231 that bind transcription factors in an allele-specific way. Representative haplotypes were cloned or constructed, nuclear protein binding and transcriptional activity were evaluated. RESULTS rs5...
متن کاملAssociation of Warfarin Therapy with APOE and VKORC1 Genes Polymorphism in Iranian Population
Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (...
متن کاملPharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1.
BACKGROUND Vitamin K epoxide reductase subunit 1 (VKORC1) is the molecular target of coumarin anticoagulants and mutations in VKORC1 have been identified previously in individuals who required high warfarin doses. OBJECTIVE Detailed characterization of the relationship between variation in VKORC1 and the warfarin resistance phenotype. PATIENTS AND METHODS Serum warfarin concentration and co...
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ژورنال
عنوان ژورنال: Cardiovascular Therapeutics
سال: 2010
ISSN: 1755-5914
DOI: 10.1111/j.1755-5922.2009.00107.x